Game of Choice, Not Chance™ is a platform for mobile games using play to empower the choices and voices of young people. The first game in a suite of games, Go Nisha Go®, was co-designed with girls in India to provide an entertaining and safe space where they may explore, discover, and learn through interactive role-play in a virtual world. Within the game, girls can experience the power of their decisions, get connected to vital information and real-world resources, and become better equipped to shape their futures with confidence. Game of Choice, Not Chance is the central component of a direct-to-consumer model for positively impacting girls’ lives through gaming innovation. The digital platform is a choice-based, story-driven mobile game, with in-game reproductive health information and linkages to relevant products and care, and an integrated game microsite where girls can dig deeper into topics introduced within the game. Game of Choice, Not Chance is a response to USAID’s interest in Direct-to-Consumer (D2C) Approaches to Fertility Awareness and Adolescent Reproductive Health. Howard Delafield International is implementing the youth-centered initiative through a consortium that includes India-based partners, Metamersive, Vihara Innovation Network, Girl Effect, Restless Development, Jubi.ai, MullenLowe Lintas Group, and U.S-based Cycle Technologies, and NAM ER Technology.